Antibirth (2016)

Lou (Natasha Lyonne) is a hard-partying stoner who lives in a run-down trailer outside a rural Michigan town where women have recently been going missing. She awakens one morning after a party at an abandoned warehouse and finds herself experiencing bizarre symptoms akin to those experienced during pregnancy. Her friend, Sadie (Chloë Sevigny), believes she is pregnant and not telling her about it, despite Lou's claims that she has no had sex with anyone in nearly a year. Lou also believes that it is impossible for her to get pregnant after an upsetting incident six months earlier when she miscarried in a club while on the toilet. After getting a ride from her friend Luke (Emmanuel Kabongo) to her cleaning job at a motel, she encounters an eccentric stranger, Lorna (Meg Tilly), who is staying in one of the hotel rooms.

Meanwhile, Gabriel (Mark Webber), Sadie's drug dealer and boyfriend, is keeping hidden in his apartment a woman who has had a grotesque physical reaction to a new drug Gabriel and his friend Warren have been selling to locals. It is revealed that Sadie, who had a child many years ago, is trying to reunite with her estranged offspring, though Gabriel is doubtful it will ever happen. In addition to running drugs (including unstable, experimental drugs, some of which turned an underling's skin inside out), Gabriel works as a pimp; during an encounter between a sex worker and a client, a strange man, apparently familiar to Gabriel and later revealed to be Isaac, watches the intercourse take place, noting his interest in the encounter.

One afternoon, Lou loses consciousness and has bizarre hallucinations in which figures from Funzone, a local family entertainment center, give her a vaginal exam. She awakens to find her stomach protruding, and a blister formed on her foot, which leaks a clear fluid after she cuts it open with a knife. When Lou regains consciousness, Lorna arrives at her trailer unannounced, and asks her if she's experienced a series of odd symptoms and mental fogginess; she claims to be clairvoyant, and noticed that Lou seemed troubled when she had met her at the motel. The two have lunch at the Funzone, and Lorna confesses that she was abducted by an unknown entity while enrolled in the military, an event which led to her being discharged when she questioned her authorities. Lou confronts Warren, who works at the Funzone, about the night before she began experiencing her symptoms; he admits that Gabriel has been "trading" women, mostly runaways, to a mysterious man named Isaac in exchange for drugs to sell.

At her trailer, Lorna shows Lou a scar on her forearm, where she claims an implant was inserted and then forcibly removed while she was in the military. Sadie arrives the next day, and suggests Lou see a doctor, but Lou insists she is not pregnant. Lou, Sadie, and Lorna go to the abandoned warehouse where the party had occurred the night before her symptoms began. There, she has a flashback of being injected with a drug by Gabriel at the party. Sadie confesses that Gabriel had used Lou as a test subject for the new drug—an experimental hormone for women—that he has been selling.

Back at Lou's trailer, Lorna attempts to give Lou a Caesarian section to remove the growth in her stomach. Instead, Lou gives birth to a grotesque, animated disembodied head. Just after the birth, Gabriel and Isaac arrive at the trailer along with another SWAT member who shoots Lorna. Isaac reveals that the military is investigating a way to create a new race that can survive the toxic atmosphere of space (which he has been to several times) and that her lifestyle of hard-drinking and drug use, as well as his secretly pumping toxins into her home, provided an ample womb for their experiment. He tells Lou that she can help him build a new, superior race, but she refuses to continue. As he explains this, arms begin to emerge from her vagina, followed by the whole of her skeleton, leaving her flesh an empty shell. The headless creature attacks and kills both Gabriel and Isaac. A SWAT member enters the trailer after hearing a commotion, and sees the trailer covered in blood, as the full-bodied creature stands in the kitchen, holding its head in its hands.