Resident Evil: The Final Chapter (2016)

Dr. James Marcus, the founder of the Umbrella Corporation, is desperate to save his daughter, Alicia, who is dying of progeria. Marcus confiscates an untested embryonic Umbrella project—the T-virus—created by his colleague Dr. Charles Ashford and uses it on Alicia and others. After a child treated with the virus becomes a zombie, Marcus immediately orders the project terminated, all data on it destroyed, and forbids Ashford from ever pursuing it again, devastating Ashford, who needed the T-virus to save his own daughter. Marcus's partner, Dr. Alexander Isaacs, has Marcus murdered by Albert Wesker, adopts Alicia, and takes over Umbrella.

In the present, Alice awakens in the ruined White House following a betrayal by Wesker. The Red Queen program appears and recruits her to infiltrate the Hive, a facility beneath Raccoon City. The Umbrella Corporation possesses an airborne antivirus capable of eliminating the T-virus plague, but is waiting for the world's few remaining humans to be wiped out in 48 hours. As her body carries the virus, Alice believes she will not survive, but accepts the mission regardless.

While traveling, Alice is captured by Isaacs, learning the "Isaacs" she previously killed was a clone. She escapes his convoy and reaches Raccoon City, where she meets a group of survivors: Doc, Abigail, Christian, Cobalt, Razor, and Claire Redfield, who survived the attack on Arcadia. Doc and Claire are in a relationship. Isaacs' convoy approaches, trailed by a horde of zombies. Alice and the group defeat them and retrieve Isaacs' few human captives, but Cobalt dies in the process. Alice and the crew enter the Hive, which Wesker controls from a central hub. He releases mutated guard dogs, killing Christian and a freed captive.

The Red Queen appears to Alice and explains that her program is in conflict, as she cannot hurt an Umbrella employee but also must value human life. She plays a video of Isaacs presenting a plan to release the T-virus, cleansing the Earth of humanity and leaving the rich and powerful—including Umbrella executives, cryogenically frozen and kept safe in the Hive—to rebuild the world. Only one voice on the Umbrella board dissents: an old woman. The Red Queen explains that she is using Alice as an agent to act against Umbrella, and warns of a traitor in the group. Abigail and Razor are killed by traps.

Alice and Doc plant bombs taken from the first infiltration team's leftover equipment and confront the real, tech-upgraded Isaacs. Doc is unmasked as Umbrella's spy, and Claire is captured by Wesker. A cryogenic capsule releases an aged Alicia Marcus, Umbrella's co-owner and Marcus' daughter, who disagreed with Wesker's plan but was outvoted. Isaacs reveals that Alice is actually a clone of Alicia; he plans to eliminate the pair and assume total control of Umbrella. Alicia fires Wesker, allowing the Red Queen to terminate his protection program and crush his leg with a security door. Doc unsuccessfully tries to shoot Alice; Claire kills him. After giving the critically-wounded Wesker a deadman's switch to the primed bombs, Alice and Claire pursue Isaacs while Alicia uploads her childhood memories into the Red Queen's mainframe.

Isaacs overpowers Alice and Claire at first, but Alice activates a grenade in his pocket, killing him. She escapes to the surface with the anti-virus, but Isaacs revives and catches her before she can release it. Before he can kill her, the Isaacs clone from the convoy arrives and murders him, believing himself to be the original Isaacs, before being devoured by the undead. Alice releases the anti-virus, killing all of the zombies around her before she passes out. Wesker simultaneously drops the deadman's switch, destroying himself, Alicia, the Hive, and the hibernating elite.

Claire wakes Alice, who survived because the anti-virus only killed the T-virus within her body, not the healthy cells. The Red Queen, itself based on a young Alicia, uploads Alicia's childhood memories into Alice, granting her a childhood and a full sense of self-identity. With the anti-virus being airborne, it will take years to spread over the entire planet. Until it does, Alice vows to continue her mission of eliminating the undead.